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In nonneuronal tissues, experimental studies have demonstrated that melatonin inhibits NO production induced by lipopolysaccharide (LPS) that induce the activation of the immune response 77
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However, some individuals may experience mild side effects such as stomach upset or allergic reactions
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Notwithstanding progress in diabetic retinopathy treatments, such as laser photocoagulation, intravitreal anti-VEGF therapy, and corticosteroids, treatment is constrained by exorbitant costs, intrusive techniques, unpleasant effects, and inconsistent patient responses
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